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Researchers discover a potential way to hit an elusive target in pancreatic cancer

 Three independent studies suggest a way to indirectly thwart a mutated gene that drives tumor growth in 95% of people with pancreatic cancer.

The changed gene, KRAS, has proven to be one of the most elusive targets in cancer research.

Currently there are no approved drugs that target mutated KRAS proteins (made from the altered KRAS gene) directly. There are drugs that target KRAS indirectly by blocking proteins that interact with it, but they have been ineffective against pancreatic cancer in clinical studies.

In these new studies, however, the researchers found that drugs that block the activity of KRAS-interacting proteins force cancer cells to rely on a way of creating energy called autophagy. They


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